Publications

2025

 

Zautner AE, Sarfo FS, Norman BR, Dompreh A, Asibey SO, Boateng R, Kuffour EO, Di Cristanziano V, Tufa TB, Feldt T, Kahlfuß S, Frickmann H, Eberhardt KA.

Comparative epidemiology of Ghanaian individuals with molecular proof of Entamoeba histolytica with and without concomitant human immunodeficiency virus infection

Eur J Microbiol Immunol (Bp). 2025 Jun 11;15(2):94-102. doi: 10.1556/1886.2025.00030. Print 2025 Jun 30.PMID: 40498573 

 

Katsoulis-Dimitriou K, Schmidt J, Roder M, Dudeck J, Philipsen L, Koch JP, Cattelan M, Schmitter L, Biskou O, Hoffmann A, Mihlan M, Sharma R, Kotrba J, Voss M, Abedi M, Sauerland I, Frischbutter S, Zielinski CE, Geffers R, Lämmermann T, Müller AJ, Kahlfuß S, Dudeck A. 

Ingestion of mast cell granules boosts macrophages and drives atypical programming

J. Allergy Clin Immunol. 2025 May 26:S0091-6749(25)00576-7. doi: 10.1016/j.jaci.2025.04.035. Online ahead of print. PMID: 40436115

 

Zhong L, Wang YH, Kahlfuss S, Jishage M, McDermott M, Yang J, Tao AY, Hu K, Noyer L, Raphael D, Patel D, Knight TE, Chitlur M, Machaca K, Feske S.

STIM1-mediated NFAT signaling synergizes with STAT1 to control T-bet expression and TH1 differentiation

Nat Immunol. 2025 Mar;26(3):484-496. doi: 10.1038/s41590-025-02089-8. Epub 2025 Feb 21.PMID: 39984734

 

Jantz-Naeem N, Guvencli N, Böttcher-Loschinski R, Böttcher M, Mougiakakos D, Kahlfuss S.

Metabolic T-cell phenotypes: from bioenergetics to function

Am J Physiol Cell Physiol. 2025 Mar 1;328(3):C1062-C1075. doi: 10.1152/ajpcell.00478.2024. Epub 2025 Feb 13.PMID: 39946684

 

Genseke S, Berisha M, Teerstegen A, Meyer B, Kaasch AJ, Färber J, Schalk E, Zautner AE, Esser T, Kahlfuß S.

Lautropia mirabilis sepsis in immunodeficiency: first report and genomic features

Infection. 2025 Feb;53(1):457-462. doi: 10.1007/s15010-024-02388-6. Epub 2024 Sep 6.PMID: 39240418

 

2024

 

Kotrba J, Müller I, Pausder A, Hoffmann A, Camp B, Boehme JD, Müller AJ, Schreiber J, Bruder D, Kahlfuss S, Dudeck A, Stegemann-Koniszewski S.

Innate players in Th2 and non-Th2 asthma: emerging roles for the epithelial cell, mast cell, and monocyte/macrophage network

Am J Physiol Cell Physiol. 2024 Dec 1;327(6):C1373-C1383. doi: 10.1152/ajpcell.00488.2024. Epub 2024 Oct 14.PMID: 39401422

 

Franz T, Stegemann-Koniszewski S, Schreiber J, Müller A, Bruder D, Dudeck A, Boehme JD, Kahlfuss S.

Metabolic and ionic control of T cells in asthma endotypes

Am J Physiol Cell Physiol. 2024 Nov 1;327(5):C1300-C1307. doi: 10.1152/ajpcell.00474.2024. Epub 2024 Oct 7.PMID: 39374078 

 

Reichardt C, Brandt S, Bernhardt A, Krause A, Lindquist JA, Weinert S, Geffers R, Franz T, Kahlfuss S, Dudeck A, Mathew A, Rana R, Isermann B, Mertens PR.

DNA-binding protein-A promotes kidney ischemia/reperfusion injury and participates in mitochondrial function

Kidney Int. 2024 Aug;106(2):241-257. doi: 10.1016/j.kint.2024.05.009. Epub 2024 May 29.PMID: 38821446

 

Kahlfuss S, Paggetti J, BöttcherM.

Editorial: Metabolic barriers in cancer and cancer therapy

Front Oncol. 2024 May 8;14:1411579. doi: 10.3389/fonc.2024.1411579. eCollection 2024.PMID: 38779089 

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Bhuria V, Franz T, Baldauf C, Böttcher M, Chatain N, Koschmieder S, Brümmendorf TH, Mougiakakos D, Schraven B, Kahlfuß S, Fischer T.

Activating mutations in JAK2 and CALR differentially affect intracellular calcium flux in store operated calcium entry

Cell Commun Signal. 2024 Mar 21;22(1):186. doi: 10.1186/s12964-024-01530-z.PMID: 38509561 ​

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Brandt S, Bernhardt A, Häberer S, Wolters K, Gehringer F, Reichardt C, Krause A, Geffers R, Kahlfuß S, Jeron A, Bruder D, Lindquist JA, Isermann B, Mertens PR.

Comparative Analysis of Acute Kidney Injury Models and Related Fibrogenic Responses: Convergence on Methylation Patterns Regulated by Cold Shock Protein

Cells. 2024 Feb 20;13(5):367. doi: 10.3390/cells13050367.PMID: 38474331

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2023

 

Baars I, Jaedtka M, Dewitz LA, Fu Y, Franz T, Mohr J, Gintschel P, Berlin H, Degen A, Freier S, Rygol SM, Schraven B,

Kahlfuss S, van Zandbergen G, Müller AJ.

Leishmania major drives host phagocyte death and cell-to-cell transfer depending on intracellular pathogen proliferation rate.

JCI Insight. 2023 Jun 13:e169020. doi: 10.1172/jci.insight.169020. Epub ahead of print. PMID: 37310793.​

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Kruse B#, Buzzai AC#, Shridhar N#, Braun AD#, Gellert S, Knauth K, Pozniak J, Peters J, Dittmann P, Mengoni M, van der Sluis TC, Höhn S, Antoranz A, Krone A, Fu Y, Yu D, Essand M, Geffers R, Mougiakakos D, Kahlfuß S, Kashkar H, Gaffal E, Bosisio FM, Bechter O, Rambow F, Marine JC, Kastenmüller W, Müller AJ*, Tüting T*.

CD4+ T cell-induced inflammatory cell death controls immune-evasive tumours.

Nature. 2023 Jun 14. doi: 10.1038/s41586-023-06199-x. Epub ahead of print. PMID: 37316667. *Corr. author  #First-authors

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​Binder R, Hahn A, Eberhardt KA, Hagen RM, Rohde H, Loderstädt U, Feldt T, Sarfo FS, Di Cristanziano V,

Kahlfuss S, Frickmann H, Zautner AE.

Comparison of the Diagnostic Accuracy of Three Real-Time PCR Assays for the Detection of Arcobacter butzleri in Human Stool Samples Targeting Different Genes in a Test Comparison without a Reference Standard.

Microorganisms. 2023 May 17;11(5):1313. doi: 10.3390/microorganisms11051313. PMID: 37317286; PMCID: PMC10223941.​

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Hoffmann K, Riediger M, Tersteegen A, Marquardt P, Kahlfuß S, Kaasch AJ, Hagen RM, Frickmann H, Zautner AE.

Molecular epidemiology of enterically colonizing Escherichia coli with resistance against third-generation cephalosporins isolated from stool samples of European soldiers with concomitant diarrhea on deployment in Western African Mali. 

Front. Microbiology. 2023 May 5;14:1169829. doi: 10.3389/fmicb.2023.1169829. PMID: 37213500; PMCID: PMC10198576.​

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Roder M and Kahlfuss S*. Implementation of Immunometabolism into Curricula, Scientific Societies, and Immunological Routine Diagnostics. 

J Immunol Sci. 2023. doi.org/10.29245/2578-3009/2022/4.1243.*Corr. author ​

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Roder M#, Franz T#, Negele J#, Schreiber J*,  Kahlfuss S*. Asthma bronchiale - Unterschiedliche Endotypen, unterschiedliche Therapien.

Deutsches Ärzteblatt. 2023. In Press.*Corr. authors 

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Jantz-Naeem N, Böttcher-Loschinski R, Borucki K, Mitchell-Flack M, Böttcher M, Schraven B, Mougiakakos D*, Kahlfuss S*. TIGIT signaling and its influence on T cell metabolism and immune cell function in the tumor microenvironment.

Front Oncology. 2023 Feb 17;13:1060112. doi: 10.3389/fonc.2023.1060112. *Corr. authors​

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2022

 

Franz T#, Negele J#, Bruno P, Böttcher M, Mitchell-Flack M, Reemts L, Krone A, Mougiakakos D, Müller AJ, Zautner AE,

Kahlfuss S*.

Pleiotropic effects of antibiotics on T cell metabolism and T cell-mediated immunity.
Front Microbiol. 2022. https://doi.org/10.3389/fmicb.2022.975436. *Corr. author  #First-authors​

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Franz T#, Negele J#, Kahlfuss S*. Cytotoxic innate lymphoid cells sense tumor-derived IL-15: A novel mechanism

of cancer immunosurveillance. 

Signal Transduction and Targeted Therapy. 2022. https://doi.org/10.1038/s41392-022-01173-x. *Corr. author  #First-authors​

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Wang Y-H#, Noyer L#, Kahlfuss S#, Raphael D, Tao AJ, Kaufmann U, Zhu J, Mitchell-Flack M, Sidhu I, Zhou F, Vaeth M, Thomas PG, Saunders SP, Stauderman K, Curotto de Lafaille MA, Feske S*. Distinct roles of ORAI1 in T cell-mediated allergic airway inflammation and immunity to influenza A virus infection.

Science Advances. 2022. https://doi.org/10.1126/sciadv.abn6552. *Corr. author #First-authors  ​

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Böttcher-Loschinski R*, Rial Saborido J, Böttcher M, Kahlfuss S, Mougiakakos D. Lipotoxicity as a Barrier for T Cell-Based Therapies.

Biomolecules. 2022; 12(9):1182. https://doi.org/10.3390/biom12091182 *Corr. author

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Böttcher M*, Böttcher-Loschinski R., Kahlfuss S., Aigner M., Gießl A., Mackensen A., Schlötzer-Schrehardt U., Tüting T., Bruns H. and Mougiakakos D*. *Corr. authors CLL-Derived Extracellular Vesicles Impair T-Cell Activation and Foster T-Cell Exhaustion via Multiple Immunological Checkpoints.

Cells. 2022. https://doi.org/10.3390/cells11142176 *Corr. authors​

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Thurm C.#, Reinhold A.#, Borucki K., Kahlfuss S., Feist E., Schreiber J., Reinhold D., and Schraven B*. Homologous and Heterologous Anti-COVID-19 Vaccination Does Not Induce New-Onset Formation of Autoantibodies Typically Accompanying Lupus Erythematodes, Rheumatoid Arthritis, Celiac Disease and Antiphospholipid Syndrome. 

Vaccines. 2022. https://doi.org/10.3390/vaccines10020333  *Corr. author  #First-authors 

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Krone A.#, Fu Y.#, Schreiber S.#, Kotrba J., Borde L. Nötzold A., Thurm C., Negele J., Franz T., Stegemann-Koniszewski S., Schreiber J., Shukla A., Geffers R., Schraven B., Reinhold D., Dudeck A., Reinhold A., Müller A., and Kahlfuss S*.

Ionic mitigation of CD4+ T cell metabolic fitness, Th1 central nervous system autoimmunity and Th2 asthmatic airway inflammation by therapeutic zinc.

Scientific reports. 2022. ​doi: 10.1038/s41598-022-04827-6 *Corr. author, #First-authors 

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2021

 

Mougiakakos D and Kahlfuss S*. 

“Moonlighting” at the power plant: how mitochondria facilitate serial killing by CD8+ cytotoxic T cells.  

Signal Transduction and Targeted Therapy. 2021. https://doi.org/10.1038/s41392-021-00846-3. *Corr. author

 

Formaglio P, Alabdullah M, Siokis A, Handschuh J, Sauerland I, Fu Y, Krone A, Gintschel P, Stettin J, Heyde S, Mohr J, Philipsen L, Schröder A, Robert PA, Zhao G, Khailaie S, Dudeck A, Bertrand J, Späth GF, Kahlfuß S, Bousso P, Schraven B, Huehn J, Binder S, Meyer-Hermann M, Müller AJ.

Nitric oxide controls proliferation of Leishmania major by inhibiting the recruitment of permissive host cells.

Immunity. 2021 Oct 15:S1074-7613(21)00406-4. doi: 10.1016/j.immuni.2021.09.021. Epub ahead of print. PMID: 34687607.

 

Thurm C, Schraven B, Kahlfuss S*.

ABC Transporters in T Cell-Mediated Physiological and Pathological Immune Responses.

Int J Mol Sci. 2021 Aug 25;22(17):9186. doi: 10.3390/ijms22179186. PMID: 34502100; PMCID: PMC8431589. *Corr. author

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Schreiber S, Hammers CM, Kaasch AJ, Schraven B, Dudeck A, Kahlfuss S*.

Metabolic Interdependency of Th2 Cell-Mediated Type 2 Immunity and the Tumor Microenvironment.

Front Immunol. 2021 May 31;12:632581. doi: 10.3389/fimmu.2021.632581. PMID: 34135885; PMCID: PMC8201396. *Corr. author

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Reinhold D, Guttek K, Reddig A, Voss L, Schubert C, Kahlfuss S, Grüngreiff K, Schraven B, Reinhold A.

Zinc Aspartate Induces IL-16 Secretion and Apoptosis in Human T Cells.

Biomedicines. 2021 Mar 1;9(3):246. doi: 10.3390/biomedicines9030246. PMID: 33804583; PMCID: PMC7998552.

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2020

 

Vaeth M, Kahlfuss S, Feske S. CRAC Channels and Calcium Signaling in T Cell-Mediated Immunity.

Trends Immunology. 2020 Oct;41(10):878-901. doi: 10.1016/j.it.2020.06.012. Epub 2020 Jul 22. PMID: 32711944; PMCID: PMC7985820.

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Kahlfuss S, Kaufmann U, Concepcion AR, Noyer L, Raphael D, Vaeth M, Yang J, Pancholi P, Maus M, Muller J, Kozhaya L, Khodadadi-Jamayran A, Sun Z, Shaw P, Unutmaz D, Stathopulos PB, Feist C, Cameron SB, Turvey SE, Feske S.

STIM1-mediated calcium influx controls antifungal immunity and the metabolic function of non-pathogenic Th17 cells.

EMBO Mol Med. 2020 Aug 7;12(8):e11592. doi: 10.15252/emmm.201911592. Epub 2020 Jul 1. PMID: 32609955; PMCID: PMC7411566.

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2019

 

Kaufmann U*, Kahlfuss S*, Yang J, Ivanova E, Koralov SB, Feske S.

Calcium Signaling Controls Pathogenic Th17 Cell-Mediated Inflammation by Regulating Mitochondrial Function.

Cell Metabolism. 2019 May 7;29(5):1104-1118.e6. doi: 10.1016/j.cmet.2019.01.019. Epub 2019 Feb 14. PMID: 30773462; PMCID: PMC6506368. *First-authors 

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Woelfer M, Kasties V, Kahlfuss S, Walter M.

The Role of Depressive Subtypes within the Neuroinflammation Hypothesis of Major Depressive Disorder.

Neuroscience. 2019 Apr 1;403:93-110. doi: 10.1016/j.neuroscience.2018.03.034. Epub 2018 Mar 29. PMID: 29604382.

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2018

 

Lian J*, Cuk M*, Kahlfuss S*, Kozhaya L, Vaeth M, Rieux-Laucat F, Picard C, Benson MJ, Jakovcevic A, Bilic K, Martinac I, Stathopulos P, Kacskovics I, Vraetz T, Speckmann C, Ehl S, Issekutz T, Unutmaz D, Feske S. ORAI1 mutations abolishing store-operated Ca2+entry cause anhidrotic ectodermal dysplasia with immunodeficiency.

J Allergy Clin Immunol. 2018 Oct;142(4):1297-1310.e11. doi: 10.1016/j.jaci.2017.10.031. Epub 2017 Nov 16. PMID: 29155098;  *First-authors 

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2016

 

Kahlfuss S*, Flieger RR, Mankertz A, Yilmaz K, Roepke TK. Pericardial Tamponade in an Adult Suffering from Acute Mumps Infection. *Corr. author

Case Rep Med. 2016;2016:7980936. doi: 10.1155/2016/7980936. Epub 2016 Oct 12. PMID: 27818687; PMCID: PMC5080511.

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Kahlfuss S*, Flieger RR, Roepke TK, Yilmaz K. Diagnosis and treatment of cardiac echinococcosis. *Corr. author

Heart. 2016 Sep 1;102(17):1348-53. doi: 10.1136/heartjnl-2016-309350. Epub 2016 May 19. PMID: 27199228.

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2014

 

Simma N, Bose T, Kahlfuss S*, Mankiewicz J, Lowinus T, Lühder F, Schüler T, Schraven B, Heine M, Bommhardt U. NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells.

Cell Commun Signal. 2014 Dec 5;12:75. doi: 10.1186/s12964-014-0075-5. PMID: 25477292; PMCID: PMC4269920. *First-authors 

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Kahlfuss S*, Simma N*, Mankiewicz J*, Bose T*, Lowinus T, Klein-Hessling S, Sprengel R, Schraven B, Heine M, Bommhardt U. Immunosuppression by N-methyl-D-aspartate receptor antagonists is mediated through inhibition of Kv1.3 and KCa3.1 channels in T cells. *First-authors 

Mol Cell Biol. 2014 Mar;34(5):820-31. doi: 10.1128/MCB.01273-13. Epub 2013 Dec 16. PMID: 24344200; PMCID: PMC4023824.